Source: http://www.about-roofing.com/home-improvement-products-that-are-wrong-for-the-job-fox-news/1215/
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Saturday, February 18, 2012
About Roofing ? Blog Archive ? Home improvement products that ...
Friday, February 17, 2012
Santorum's Surge, Part II: The Sweater-Vest Strikes Back (Time.com)
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Romance & Real Estate: How Your Housing Situation Affects Your Love Life (Time.com)
Nick Dolding / Getty Images
Where you live affects who you date?and who will absolutely refuse to date you. In honor of Valentine?s Day, the real estate website Trulia commissioned Harris Interactive to conduct a survey looking at the intersection of attitudes about housing and romance. Are homeowners regarded as ?marriage material? more so than noncommital renters? Are people more interested in potential mates if they live alone? Just how bad is your love life impacted if you live with your parents? When it comes to dating and housing, what?s hot and what?s not?
Owners vs. Renters
While owning a home has always been a part of the traditional American Dream, it?s apparently not a deal breaker (or maker) when it comes to dating. Nearly two-thirds (63%) of unmarried U.S. adults said that homeowners had no significant ?home advantage? in terms of attracting dates. Only 28% of those surveyed said they?d prefer someone who owned a home. So you can?t really use the fact that you?re a renter as an excuse for why you can?t find a date. Well, perhaps guys can use that more as an excuse than the ladies: While just 19% of men say that they have a preference for dating homeowners, 36% of women prefer dates who own property.
(MORE: Who Qualifies for the $26 Billion Foreclosure Settlement?)
Buying a home demonstrates some level of commitment. But for the most part, owning a home is not viewed as a sign that you?re ready, or even interested, in marriage. In the survey, 43% of unmarried U.S. adults said that homeownership is not an indication of a person?s desire to get married or be in a serious, long-term committed relationship. However, young people are more likely to view homeowners as capable of committing to a partner. A higher percentage of millenials equate homeownership to stability and commitment. Baby Boomers, by contrast, are generally past the stage of first-time homeownership, so it matters less to them in terms of viewing the commitment potential of a new partner.
Lose the Roommate
The majority of those surveyed (62%) say they?d rather date someone who lives alone. Location matters too: When comparing the preferences of men and women, Trulia found that more men would rather date someone who lives alone in a big city. On the flip side, more women would go for a date with someone who lives solo in a house in the ?burbs.
Move Out Already!
Nearly 25 million adults live at home with their parents because they?re unemployed or underemployed, they?re trying to pay off student loans or save money to buy a place, or for any number of other reasons. While calling mom and dad your ?roommates? may be a smart financial move, it?s the kiss of death for a healthy dating life. Trulia?s survey found that only 5% of unmarried adults would be open to dating someone who lived with their parents.
(MORE: More Young Adults Are Poor, Live With Their Parents)
Shacking Up to Save
Nearly three-quarters (74%) of unmarried renters said they?d be willing to consider living with their significant other in order to save money. Somewhat surprisingly, more men than women said they?d be very willing to make the commitment of cohabitation.
Everyone Loves Master Bathrooms
Trulia posed the question: ?If you were in the market for your first home today, what home amenities would make you fall in love with a home?? The results show that, for the most part, men and women largely want the same things. The top amenity for both sexes is a master bathroom, followed by a walk-in closet. More women (72%) are infatuated with a walk-in closet than men (55%), but there are apparently plenty of metrosexual males in need of closet space, as well as a gourmet kitchen?No. 3 on the list of most-desired home amenities for both sexes. Perhaps men and women aren?t as different as we?ve been led to believe.
Michael Corbett is the?real estate and lifestyle expert at Trulia, an?online real estate resource. He is also the host of NBC?s ?EXTRA?s Mansions and Millionaires;? appears regularly on ABC?s ?The View? and Fox News; and is author of three real estate books: Find It, Fix It, FLIP IT!; Ready, Set, SOLD! and Before You BUY!
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Thursday, February 16, 2012
Racquetball Equipment by Racquetball Factory - Free Url Directory
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Source: http://www.urlz.eu/link/8541/Racquetball-Equipment-by-Racquetball-Factory
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Wednesday, February 15, 2012
food and drink ? Blog Archive ? Walnut Chocolate Rum Balls
1 c Walnuts, ground or finely chopped
2 c Grated ?German?s sweet? or bittersweet chocolate
1 1/2 c Sifted confectioner?s sugar
4 tb Rum
Cocoa powder
Combine nuts, sugar, and chocolate. Moisten with rum to form a
stiff dough. Form into small balls and roll in cocoa to coat. This
recipe is not only simple, it?s flexible. It can be made with other
kinds of liquor (amaretto, sherry, and Southern Comfort work well),
nuts (almonds or pecans, for instance) and coatings (ground nuts,
finely grated coconut, etc.) and always comes out tasting great.
Adding small chunks of nut for texture is also effective.
Source: http://oregonfarmblog.com/2012/02/walnut-chocolate-rum-balls-2/
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Apple releases 'GarageBand for authors'
Source: http://mobile.wnd.com/2012/02/apple-releases-garageband-for-authors/
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Monday, February 13, 2012
A mitosis mystery solved: How chromosomes align perfectly in a dividing cell
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_uQ5xedpvreIhGEHawoMtrJ0lYOzji3d__AEr-DPHWVA0Ilylp2LEjlXxmuMMW_IFe1xkQodQRaLJtmS5uW3BR0w4jp6eYOMJ2RoUHkzBA=s0-d){kind=small}
Public release date: 12-Feb-2012[ | E-mail |
Share ] Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
CAMBRIDGE, Mass. (February 12, 2012) To solve a mystery, sometimes a great detective need only study the clues in front of him. Like Agatha Christie's Hercule Poirot and Arthur Conan Doyle's Sherlock Holmes, Tomomi Kiyomitsu used his keen powers of observation to solve a puzzle that had mystified researchers for years: in a cell undergoing mitotic cell division, what internal signals cause its chromosomes to align on a center axis?
"People have been looking at these proteins and players in mitosis for decades, and no one ever saw what Tomomi observed," says Whitehead Institute Member Iain Cheeseman. "And it's very clear that these things are happening. These are very strong regulatory paradigms that are setting down these cell division axes. And careful cell biology allowed him to see that this was occurring. People have been looking at this for a long time, but never with the careful eyes he brought to it."
Kiyomitsu, a postdoctoral researcher in Cheeseman's lab, published his work in this week's issue of the journal Nature Cell Biology.
The process of mitotic cell division has been studied intensely for more than 50 years. Using fluorescence microscopy, today's scientists can see the tug-of-war cells undergo as they move through mitosis. Thread-like proteins, called microtubules, extend from one of two spindle poles on either side of the cell and attempt to latch onto the duplicated chromosomes. This entire "spindle" structure acts to physically distribute the chromosomes, but it is not free floating in the cell. In addition to microtubules from both spindle poles that attach to all of the chromosomes, astral microtubules that are connected to the cell cortexa protein layer lining the cell membraneact to pull the spindle poles back and forth within the cell until the spindle and chromosomes align down the center axis of the cell. Then the microtubules tear the duplicated chromosomes in half, so that ultimately one copy of each chromosome ends up in each of the new daughter cells.
The process of mitosis is extremely precise; when it comes to manipulating DNA, cells verge on being obsessive and with good reason. Gaining or losing a chromosome during cell division can lead to cell death, developmental disorders, or cancer.
As Kiyomitsu watched mitosis unfold in symmetrically dividing human cells, he noticed that when the spindle oscillates toward the cell's center, a partial halo of the protein dynein lines the cell cortex on the side farther away from the spindle. As the spindle swings to the left, dynein appears on the right, but when the spindle swing to the right, dynein vanishes and reappears on the left side.
For Kiyomitsu, the key to the alignment mystery was dynein, which is known as a motor protein that "walks" molecular cargoes along microtubules. Kiyomitsu determined that in this case, dynein is anchored to the cell cortex by a complex that includes the protein LGN, short for leucine-glycine-asparagine-enriched protein. Instead of moving along an astral microtubule, the stationary dynein acts as a winch to pull on the spindle pole, and the microtubules and chromosomes attached to it, toward the cell cortex.
Kiyomitsu found that when a spindle pole comes within close proximity to the cell cortex, a signal from a protein called Polo-like kinase 1 (Plk1) emanates from the spindle pole, knocking dynein off of LGN and the cell cortex, stopping the spindle pole's forward motion, and freeing dynein to move to the opposite side of the cell. These oscillations continue with decreasing amplitude until the spindle settles along the cell's center axis.
As he was deciphering dynein's role in spindle alignment, Kiyomitsu noticed that a layer of LGN extends all around the cell cortex, except in the areas that are closest to the chromosomes. As the chromosomes swing back and forth, the area cleared of LGN changes in response. Because dynein needs to anchor to LGN, this cleared area ensures that dynein can only attach and pull to the right and left of the aligning chromosomes, rather than from above and below.
After testing a couple of signaling molecules associated with chromosomes, Kiyomitsu determined that a signal from the chromosomes, involving the ras-related nuclear protein (Ran), blocks LGN, and therefore dynein, from attaching to the cell cortex closest to the chromosomes. Ran bound to guanosine-5'-triphosphate (Ran-GTP), which controls nuclear import in the interphase stage of mitosis, had previously been suggested to control spindle assembly during mitosis in germ cells, but roles for the Ran gradient in mitotic non-germ cells were unclear. Kiyomitsu's work suggests a key role for Ran in directing spindle orientation.
Kiyomitsu says the axis that the spindle poles travel along is crucial to cells.
"The spindle orientation is critical for maintaining the balance between stem cells and mature cells during development," he notes. "And if this orientation becomes dysregulated or misregulated, it is reported that this may contribute to causing cancer even if chromosomes are properly segregated."
###
This work was supported by the Massachusetts Life Sciences Center, the Searle Scholars Program, and the Human Frontiers Science Foundation, the National Institutes of Health (NIH)/National Institute of General Medical Sciences, and the American Cancer Society.
Written by Nicole Giese Rura
Iain Cheeseman's primary affiliation is with Whitehead Institute for Biomedical Research, where his laboratory is located and all his research is conducted. He is also an assistant professor of biology at Massachusetts Institute of Technology.
Full Citation:
"Chromosome and spindle pole-derived signals generate an intrinsic code for spindle position and orientation"
Nature Cell Biology, published online February 12, 2012
Tomomi Kiyomitsu (1) and Iain M. Cheeseman (1)
1. Whitehead Institute, Nine Cambridge Center Cambridge, MA 02142
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 12-Feb-2012[ | E-mail |
Share ] Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
CAMBRIDGE, Mass. (February 12, 2012) To solve a mystery, sometimes a great detective need only study the clues in front of him. Like Agatha Christie's Hercule Poirot and Arthur Conan Doyle's Sherlock Holmes, Tomomi Kiyomitsu used his keen powers of observation to solve a puzzle that had mystified researchers for years: in a cell undergoing mitotic cell division, what internal signals cause its chromosomes to align on a center axis?
"People have been looking at these proteins and players in mitosis for decades, and no one ever saw what Tomomi observed," says Whitehead Institute Member Iain Cheeseman. "And it's very clear that these things are happening. These are very strong regulatory paradigms that are setting down these cell division axes. And careful cell biology allowed him to see that this was occurring. People have been looking at this for a long time, but never with the careful eyes he brought to it."
Kiyomitsu, a postdoctoral researcher in Cheeseman's lab, published his work in this week's issue of the journal Nature Cell Biology.
The process of mitotic cell division has been studied intensely for more than 50 years. Using fluorescence microscopy, today's scientists can see the tug-of-war cells undergo as they move through mitosis. Thread-like proteins, called microtubules, extend from one of two spindle poles on either side of the cell and attempt to latch onto the duplicated chromosomes. This entire "spindle" structure acts to physically distribute the chromosomes, but it is not free floating in the cell. In addition to microtubules from both spindle poles that attach to all of the chromosomes, astral microtubules that are connected to the cell cortexa protein layer lining the cell membraneact to pull the spindle poles back and forth within the cell until the spindle and chromosomes align down the center axis of the cell. Then the microtubules tear the duplicated chromosomes in half, so that ultimately one copy of each chromosome ends up in each of the new daughter cells.
The process of mitosis is extremely precise; when it comes to manipulating DNA, cells verge on being obsessive and with good reason. Gaining or losing a chromosome during cell division can lead to cell death, developmental disorders, or cancer.
As Kiyomitsu watched mitosis unfold in symmetrically dividing human cells, he noticed that when the spindle oscillates toward the cell's center, a partial halo of the protein dynein lines the cell cortex on the side farther away from the spindle. As the spindle swings to the left, dynein appears on the right, but when the spindle swing to the right, dynein vanishes and reappears on the left side.
For Kiyomitsu, the key to the alignment mystery was dynein, which is known as a motor protein that "walks" molecular cargoes along microtubules. Kiyomitsu determined that in this case, dynein is anchored to the cell cortex by a complex that includes the protein LGN, short for leucine-glycine-asparagine-enriched protein. Instead of moving along an astral microtubule, the stationary dynein acts as a winch to pull on the spindle pole, and the microtubules and chromosomes attached to it, toward the cell cortex.
Kiyomitsu found that when a spindle pole comes within close proximity to the cell cortex, a signal from a protein called Polo-like kinase 1 (Plk1) emanates from the spindle pole, knocking dynein off of LGN and the cell cortex, stopping the spindle pole's forward motion, and freeing dynein to move to the opposite side of the cell. These oscillations continue with decreasing amplitude until the spindle settles along the cell's center axis.
As he was deciphering dynein's role in spindle alignment, Kiyomitsu noticed that a layer of LGN extends all around the cell cortex, except in the areas that are closest to the chromosomes. As the chromosomes swing back and forth, the area cleared of LGN changes in response. Because dynein needs to anchor to LGN, this cleared area ensures that dynein can only attach and pull to the right and left of the aligning chromosomes, rather than from above and below.
After testing a couple of signaling molecules associated with chromosomes, Kiyomitsu determined that a signal from the chromosomes, involving the ras-related nuclear protein (Ran), blocks LGN, and therefore dynein, from attaching to the cell cortex closest to the chromosomes. Ran bound to guanosine-5'-triphosphate (Ran-GTP), which controls nuclear import in the interphase stage of mitosis, had previously been suggested to control spindle assembly during mitosis in germ cells, but roles for the Ran gradient in mitotic non-germ cells were unclear. Kiyomitsu's work suggests a key role for Ran in directing spindle orientation.
Kiyomitsu says the axis that the spindle poles travel along is crucial to cells.
"The spindle orientation is critical for maintaining the balance between stem cells and mature cells during development," he notes. "And if this orientation becomes dysregulated or misregulated, it is reported that this may contribute to causing cancer even if chromosomes are properly segregated."
###
This work was supported by the Massachusetts Life Sciences Center, the Searle Scholars Program, and the Human Frontiers Science Foundation, the National Institutes of Health (NIH)/National Institute of General Medical Sciences, and the American Cancer Society.
Written by Nicole Giese Rura
Iain Cheeseman's primary affiliation is with Whitehead Institute for Biomedical Research, where his laboratory is located and all his research is conducted. He is also an assistant professor of biology at Massachusetts Institute of Technology.
Full Citation:
"Chromosome and spindle pole-derived signals generate an intrinsic code for spindle position and orientation"
Nature Cell Biology, published online February 12, 2012
Tomomi Kiyomitsu (1) and Iain M. Cheeseman (1)
1. Whitehead Institute, Nine Cambridge Center Cambridge, MA 02142
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-02/wifb-amm020812.php
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